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. 2021 Aug 31;22(17):9472. doi: 10.3390/ijms22179472

Table 10.

Endocannabinoid-like compounds (fatty-acid ethanolamides) that interact with receptors outside of CB1R and CB2R.

Endocannabinoid-Like Compounds (Fatty-Acid Ethanolamides) Biological Effect(s) and/or Mechanism of Action Reference
i. OEA (an endogenous PPAR-α agonist)
  • -

    Satiety-induction

  • -

    Weight reduction

  • -

    Anti-inflammation


Via binding to peroxisome proliferators-activate receptor-α (PPAR- α)		 [136]
ii. Palmitoylethanolamide (PEA)
  • -

    Anti-inflammation

 [136]
iii. N-oleoyl-ethanolamide May act as an alternative substrate for FAAH, and in doing so, inhibit the degradation of AEA [383,384]
iv. N-linoleoyl-ethanolamide May act as an alternative substrate for FAAH, and in doing so, inhibit the degradation of AEA [383,384]
v. N-arachidonoyl-glycine May act as an alternative substrate for FAAH, and in doing so, inhibit the degradation of AEA [384,385,386]
vi. N-acyl-taurine May act as an alternative substrate for FAAH, and in doing so, inhibit the degradation of AEA [383,384,387]
vii. N-palmitoyl-ethanolamide Reduced expression of FAAH [384,388]