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. 2021 Aug 31;22(17):9472. doi: 10.3390/ijms22179472

Table 11.

Synthetic cannabinergic agonists.

Synthetic Cannabinergic Agonists Biological Effect(s) and/or Mechanism Of Action Reference
i. WIN55212-2 (Winthrop)
  • -

    A mixed R/CB2R agonist.

  • -

    Penetrates the CNS.
  • -

    Inhibits heroin-seeking behaviour in rats

  • -

    Attenuates neurological damage and reduces infarct size in artery occlusion in rats

  • -

    Reduction in glial damage after hypoxic-ischemic brain injury in preterm lambs

  • -

    Antinociceptive activity in rat pain models

 [6,58,136,389,390]
ii. CP-55940 (Pfizer)
  • -

    Inhibits heroin-seeking behaviour in rats

 [136]
iii. URB-597 (aka KDS-4103) (targets FAAH)
  • -

    Anxiety, cannabis-dependence, and hyperalgesia

  • -

    Anti-depression

 [391]
[6]
iv. PF-04457845 (Pfizer—targets FAAH) Pain disorders (including osteoarthritis) [342]
v. V158866 (Pfizer—targets FAAG) Pain disorders (including osteoarthritis) [6]