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. 2021 Aug 31;13(17):4405. doi: 10.3390/cancers13174405

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of niraparib treatment on apoptosis, caspase3/7 activity and anti-apoptotic proteins: Apoptosis index of (A) KMCH-1 or (B) CHNG31 after niraparib treatment for 72 h. Bar graphs showing the percentage of apoptotic cells after vehicle or niraparib treatment. Caspase3/7 activity analysis of (C) KMCH-1 or (D) CHNG31 after niraparib treatment for 72 h. Bar graphs showing the percentage of caspase3/7 activity after vehicle or niraparib treatment. (E–H) Western blot analysis of BCL2, BCL-XL and MCL1 after niraparib treatment for 48 h in KMCH-1, HuCCT1, CHNG6 and CHNG31, respectively. * p < 0.05. p values were calculated using the two-sided Student’s t test and data presented as mean + stdev.