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. 2021 Aug 31;22(17):9459. doi: 10.3390/ijms22179459

Figure 2.

Figure 2

Cytokine profile of gastric mucosa CagY-specific CD4+ T cell clones obtained from H. pylori-infected patients with gastric low-grade MALT lymphoma. Th clones were tested for cytokine production (A,B). CagY-specific Th clones were stimulated with CagY and TNF-α and IL-4, IFN-γ and IL-17 production was measured in culture supernatants. In unstimulated cultures, levels of TNF-α, IL-4, IFN-γ and IL-17 were consistently < 20 pg/mL. CD4+ T cell clones producing IFN-γ, but not IL-17 nor IL-4, were coded as Th1. CD4+ T cell clones producing IL-17, but not IFN-γ nor IL-4, were coded as Th17. CD4+ T cell clones producing IFN-γ, and IL-17, but not IL-4, were coded as Th17/Th1. CD4+ T cell clones producing TNF-α and IL-4, but not IL-17, were coded as Th0.