Table 1.

Overview of proteins and substances found mounted in paired helical filaments and neurofibrillary tangles.

Category	Proteins/Substances	Reference
Tubulin interacting proteins	microtubule-associated protein 2	[122]
	microtubule-associated protein 1B	[123,124]
	neurofilament proteins, vimentin	[125]
	heparansulfate proteoglycans	[126,127]
	amyloid precursor protein	[128,129]
Kinases and other cytosol enzymes	casein kinase II	[130]
	extracellular signal-related kinase-2	[131]
	glycogen synthase kinase-3	[132]
	phospholipase C-δ	[133]
Stress molecules	advanced glycation end products	[134,135,136]
	malondialdehyde	[137]
	heme oxygenase-1	[136]
Amyloid and amyloid-binding proteins	complement proteins (Clq, C3, C4d and C5b-9)	[138,139]
	vitronectin	[140]
	apolipoprotein-E	[141,142]
Others	C-series of gangliosides	[124]
	ubiquitin and ubiquitin ligases	[143,144,145]
	synaptophysin	[146]
	anti-thrombin III	[147]
	lactotransferrin	[148]