Table 3.

Overview of protein phosphatases interacting with tau protein and their roles in pathology.

Protein	Roles in Tau Pathology	References
PPP1C (A, B, C)	downregulated in AD; neuroprotective function by reducing hyperphosphorylated tau levels;	[170,222]
PPP2C (A, B)	downregulated in AD what induces tau hyperphosphorylation; neuroprotective; regulate autophagic degradation of proteins	[170,222,223,224]
PPP5C	downregulated in AD what contributes to increased levels of hyperphosphorylated tau; dephosphorylates AD phospho-tau; protects against Aβ toxicity	[225,226,227]
PTPN11	upregulated in AD; unknown role in tau pathology	[228]