Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 25;22(17):9178. doi: 10.3390/ijms22179178

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Long non-coding RNAs (lncRNAs) ZNF503-AS1 (zinc finger protein 503 antisense RNA 2) and LINC00167 inhibit the dedifferentiation of retinal pigment epithelium (RPE) cells, important in age-related macular degeneration (AMD). These lncRNAs act as an antisense inhibitor and sponge for micro RNAs, respectively. ZNF503-AS1 targets mRNA of the ZNF503 gene as it has a complementary sequence and prevents its translation resulting in the inhibition of dedifferentiation of RPE cells. LINC00167 acts as a sponge for miR-203a-3p restoring the activity of the suppressor of cytokine signaling 3 (SOCS3), which further inhibited the Janus kinase (JAK)/signal transducer and activator of transcription (STAT), resulting in the inhibition of dedifferentiation of RPE cells.