Table 4.

Diagnostic performance parameters of the ultrasound risk stratification system (RSSs) for the differentiation between benign and malignant thyroid nodules (TNs).

Diagnostic Parameters	Kwak- TIRADS	ACR TI-RADS	EU- TIRADS	Korean- TIRADS	ATA Guidelines
Cut-off (benign vs. malignant)	4c	TR5	5	high	high
PPV	0.4	0.38	0.32	0.45	0.42
(CI-95)	(0.36–0.43)	(0.35–0.42)	(0.30–0.34)	(0.41–0.49)	(0.38–0.46)
NPV	0.94	0.93	0.96	0.93	0.95
(CI-95)	(0.92–0.95)	(0.92–0.94)	(0.94–0.97)	(0.92–0.94)	(0.93–0.96)
Sensitivity	0.7	0.68	0.84	0.67	0.77
(CI-95)	(0.64–0.76)	(0.61–0.74)	(0.78–0.88)	(0.60–0.73)	(0.70–0.83)
Specificity	0.8	0.8	0.67	0.85	0.8
(CI-95)	(0.78–0.82)	(0.77–0.82)	(0.64–0.70)	(0.82–0.87)	(0.77–0.82)
ACC	0.79	0.78	0.7	0.82	0.79
(CI-95)	(0.76–0.81)	(0.75–0.80)	(0.67–0.72)	(0.79–0.84)	(0.77–0.82)
LHR+	3.54	3.34	2.55	4.4	3.79
(CI-95)	(3.04–4.13)	(2.86–3.91)	(2.29–2.84)	(3.69–5.25)	(3.23–4.42)
LHR-	0.37	0.41	0.25	0.39	0.29
(CI-95)	(0.30–0.46)	(0.33–0.50)	(0.18–0.34)	(0.32–0.48)	(0.22–0.38)
DOR	9.58	8.26	10.4	11.37	13.08
(CI-95)	(6.78–13.57)	(5.88–11.62)	(6.93–15.62)	(8.03–16.11)	(8.87–19.30)

Abbreviations: RSS—Risk Stratification Systems; PPV—Positive Predictive Value; CI-95—95% Confidence Intervals; NPV—Negative Predictive Value; ACC—Diagnostic Accuracy; LHR+—Positive Likelihood ratio; LHR—Negative Likelihood ratio; DOR—Diagnostic Odds Ratio; TIRADS/TI-RADS—Thyroid Imaging and Reporting Data System; ATA—American Thyroid Association. Thyroid nodules (TNs) that were not classifiable (N/A) are not included.