Table 6.

Overview of meta-analyses regarding the diagnostic performance of ultrasound risk stratification systems (RSSs) for thyroid nodules (TNs).

Author, Year	No of Studies (TNs)	RSSs	Sensitivity Pooled (CI-95)	Specificity Pooled (CI-95)	LHR+ Pooled (CI-95)	LHR- Pooled (CI-95)	DOR Pooled (CI-95)	AUC on ROC
Wei et al., 2016 [39]	12 (10,437)	mixed	0.79	0.71	6.62	0.2	35.2	0.918
		TIRADS	(0.77–0.81)	(0.70–0.72)	(4.39–9.99)	(0.14–0.29)	(19.5–63.4)
Migda et al., 2018 [40]	6 (10,926)	Kwak	0.98	0.55	2.67	0.05	51	0.938
			(0.98–0.99)	(0.54–0.56)	(1.69–4.20)	(0.04–0.07)	(15.2–170.8)
Kim et al., 2020 [41]	29 (33,748)	ACR	0.66	0.91				0.89
			(0.56–0.75)	(0.87–0.94)
		ATA	0.74	0.88				0.9
			(0.62–0.84)	(0.82–0.93)
		Korean	0.55	0.95				0.88
			(0.38–0.70)	(0.90–0.98)
		EU	0.82	0.9				0.91
			(0.71–0.89)	(0.77–0.96)
Kim et al., 2020 [42]	34 (37,585)	ACR	0.7	0.89
			(0.61–0.79)	(0.85–0.92)
		Korean	0.64	0.93
			(0.58–0.70)	(0.91–0.95)
		EU	0.78	0.89
			(0.64–0.88)	(0.77–95)
Castellana et al., 2020 [43]	12 (18,750)	ACR	0.74	0.64	1.9	0.4	4.9
			(0.61–0.83)	(0.56–0.70)	(1.6–2.3)	(0.3–0.6)	(3.1–7.7)
		ATA	0.87	0.31	1.2	0.4	3.1
			(0.75–0.94)	(0.24–0.40)	(1.0–1.4)	(0.2–0.7)	(1.3–7.1)
		EU	0.54	0.53	1.4	0.6	2.2
			(0.51–0.57)	(0.51–0.55)	(1.0–1.8)	(0.4–1.0)	(0.9–5.1)
		Korean	0.86	0.28	1.2	0.5	2.5
			(0.73–0.94)	(0.20–0.38)	(1.0–1.4)	(0.2–1.0)	(1.1–5.5)

Abbreviations: RSSs—Risk Stratification Systems; TNs—Thyroid Nodules; LHR+—Positive Likelihood Ratio; LHR-—Negative Likelihood Ratio; DOR—Diagnostic Odds Ratio; AUC—Area Under The Curve; ROC—Receiver Operating Curves; CI-95—95% Confidence Intervals; TIRADS—Thyroid Imaging Reporting and Data System; ACR—American College of Radiology; EU—European Union; ATA—American Thyroid Association.