Table 2.

Summary of genetic variants of individual FcRs and related diseases.

Fc Receptor	Genetic Variant						Related Diseases
	Polymorphism					Copy Number Variant
	Promoter Region		Extracellular Domain	Transmembrane Domain	Intracellular Domain
FcγRIIa			H131R				R131 allele: Bacterial infection (Low affinity to IgG2)
FcγRIIb	−120T/A −343G/C −386G/C						−343G, −386C−120A allele: SLE (High FcγRIIb expression)
FcγRIIIa			48L/R/H V158F				F131 allele: Cancer (Low affinity to IgG)
FcγRIIIb			NA1 NA2 SH				NA2 allele: CGD (Low affinity to IgG1 and IgG3)
FcRn						VNTR1- VNTR5	NA
FcεRI	α-subunit	−66T/C −344C/T					−66T, −344T allele: Allergic diseases (High FcεRI expression)
	β-subunit	−109C/T		I181L V183L	E237G		−109T allele: Asthma (High FcεRI expression) L181, L183 allele: Atopy, Asthma (Altered signaling pathway leading to cell activation) G237 allele: Allergy diseases (Activating signal induction)
	γ-subunit	−237A/G					−237A allele: AIA (High FcεRI expression)
FcαRI	−114C/T +56C/T				S248G		−114C, +56C allele: IgAN (High FcαRI expression) G248 allele: SLE (Altered signaling pathway leading to cell activation)

NA: not analyzable.