Figure 7.

Comparative transcriptional alterations in glycosphingolipids and ceramides metabolic pathways in the spinal cord of SOD1 mice at early and late symptomatic disease stages. (A) The heatmap of the combination of the six transcriptomic studies (three early symptomatic and three late symptomatic) shows the expression level of the altered genes that participate in the glycosphingolipids metabolic pathways. The heatmap colours indicate the expression levels by the log2-fold-change. Each column represents an individual RNA-seq study, and each row represents one gene. (B) The sphingolipids and ceramides biosynthesis pathways are represented, comparing the results from the Early MA and the Late MA. Coloured genes indicate that the gene was significantly altered in the meta-analysis. Blue indicates downregulation and red indicates upregulation.