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. 2021 Sep 3;22(17):9566. doi: 10.3390/ijms22179566

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Bioinformatic analysis of proteomic cluster 4. Gene Ontology (GO) analysis of proteomic cluster 4. The pie chart shows groups of color-coded GO terms for (A) biological processes (B) and molecular functions based on proteomic data from GBM cell isolates of cluster 4. (C) The pie chart shows prevalent Reactome pathway terms enriched in proteomic cluster 4 GBM members. (D) Reactome pathway network of proteomic cluster 4 showing a signaling network of several inter-connected signaling nodes (color-coded), including major signaling hubs related to signaling factors IGF/IGFBPs, IL4/13/17, NOTCH2, and complement cascade. * and ** indicate the level of significance GO terms at p < 0.01 and p < 0.001, respectively.

Bioinformatic analysis of proteomic cluster 4. Gene Ontology (GO) analysis of proteomic cluster 4. The pie chart shows groups of color-coded GO terms for (A) biological processes (B) and molecular functions based on proteomic data from GBM cell isolates of cluster 4. (C) The pie chart shows prevalent Reactome pathway terms enriched in proteomic cluster 4 GBM members. (D) Reactome pathway network of proteomic cluster 4 showing a signaling network of several inter-connected signaling nodes (color-coded), including major signaling hubs related to signaling factors IGF/IGFBPs, IL4/13/17, NOTCH2, and complement cascade. * and ** indicate the level of significance GO terms at p < 0.01 and p < 0.001, respectively.