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. 2021 Aug 30;22(17):9440. doi: 10.3390/ijms22179440

Figure 1.

Figure 1

TP-3654 resensitizes ABCG2-overexpressing cancer cells to cytotoxic anticancer drugs. The cytotoxicity of mitoxantrone, SN-38, and topotecan was determined in ABCG2-overexpressing S1-M1-80 (A–C, left panels) and drug-sensitive parental S1 (A–C, right panels) cancer cells, ABCG2-overexpressing H460-MX20 (D–F, left panels), and drug-sensitive H460 (D–F, right panels) cancer cells, as well as ABCG2-transfected R482-HEK293 (G–I, left panels) and parental HEK293 (G–I, right panels) cells in the presence of DMSO (open circles) or TP-3654 at 100 nM (open squares), 200 nM (filled squares), 300 nM (open triangles), or 500 nM (filled triangles). Data represent means ± S.E.M. from at least three independent experiments.