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. 2021 Aug 26;22(17):9232. doi: 10.3390/ijms22179232

Figure 2.

Figure 2

Relative NF-κB promoter-linked Gaussian Luciferase activity in PANC-1 NF-κB cells. PANC-1 NF-κB cells were stimulated with (A) 30 ng/mL TNFα, (B) 0.3 µM, 3 µM, or 30 µM PAR, or co-treated with TNFα and PAR and luciferase measured after (A) 0, 0.5, 1, 3, 6, and 24 h, or (B,C) 24 h. (D) PANC-1 NF-κB cells were non-treated, treated with 100 ng/mL LPS +/− different concentrations of PAR (0.3, 3, 30 µM) or TAK-242 (1, 10, 50 µM) and luciferase was measured after 6 h. Post-ANOVA, multiple comparisons relative to the control were performed using Dunnett’s test. Error bar = SD. n = 6; * p < 0.05; *** p < 0.001.