Table 1.
Inter-observer agreement between pathologists scoring sTILs in circulation 1 and 2.
| sTILs | Circulation 1 a (n = 23) | Circulation 1 a (n = 14) | Circulation 2 (n = 14) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| (%) | ICC | 95% CI | p Value | ICC | 95% CI | p Value | ICC | 95% CI | p Value b |
| Absolute values | |||||||||
| 0.634 | 0.539–0.735 | <0.001 | 0.662 | 0.566–0.760 | <0.001 | 0.798 | 0.727–0.864 | <0.001 | |
| Cutpoints | |||||||||
| ≥10 ≥20 |
0.368 0.484 |
0.278–0.488 0.385–0.603 |
<0.001 <0.001 |
0.426 0.492 |
0.324–0.551 0.388–0.614 |
<0.001 <0.001 |
0.486 0.657 |
0.382–0.608 0.561–0.756 |
<0.001 <0.001 |
| ≥25 | 0.573 | 0.475–0.684 | <0.001 | 0.602 | 0.501–0.711 | <0.001 | 0.596 | 0.495–0.706 | <0.001 |
| ≥30 | 0.537 | 0.438–0.652 | <0.001 | 0.555 | 0.451–0.671 | <0.001 | 0.597 | 0.495–0.706 | <0.001 |
| ≥40 | 0.488 | 0.389–0.606 | <0.001 | 0.506 | 0.401–0.626 | <0.001 | 0.644 | 0.546–0.745 | <0.001 |
| ≥50 | 0.428 | 0.332–0.549 | <0.001 | 0.440 | 0.337–0.564 | <0.001 | 0.569 | 0.465–0.682 | <0.001 |
| ≥60 | 0.351 | 0.263–0.470 | <0.001 | 0.368 | 0.271–0.493 | <0.001 | 0.479 | 0.375–0.602 | <0.001 |
a For circulation 1, inter-observer agreement is given for all 23 pathologists and separately for the 14 pathologists who undertook circulation 2. b A statistically significant value for the absolute values and cutpoints supports the interpretation that there is sufficient evidence in the sample to conclude that the relationships exist in the population. CI, confidence interval; ICC, intra-class correlation coefficient.