Table 4.
Target proteins in 17 signaling pathways enrichment related to gout.
| KEGG ID & Description | Target Proteins | False Discovery Rate |
|---|---|---|
| hsa04917:Prolactin signaling pathway | AKT1,CCND1,ESR1,ESR2,CYP17A1 | 0.0004 |
| hsa04370:VEGF signaling pathway | AKT1,SPHK2,PRKCA,PLA2G4A | 0.0019 |
| hsa04152:AMPK signaling pathway | AKT1,CCND1,PPARG,SCD,HMGCR | 0.0019 |
| hsa04071:Sphingolipid signaling pathway | AKT1,S1PR1,S1PR3,SPHK2,PRKCA | 0.0019 |
| hsa04915:Estrogen signaling pathway | AKT1,GABBR1,ESR1,ESR2,HSPA8 | 0.0022 |
| hsa03320:PPAR signaling pathway | PPARA,PPARG,PPAR,SCD | 0.0024 |
| hsa04066:HIF-1 signaling pathway | AKT1,GAPDH,TLR4,PRKCA | 0.0045 |
| hsa04919:Thyroid hormone signaling pathway | AKT1,CCND1,ESR1 | 0.0069 |
| hsa04664:Fc epsilon RI signaling pathway | AKT1,PRKCA,PLA2G4A | 0.012 |
| hsa04072:Phospholipase D signaling pathway | AKT1,SPHK2,PRKCA,PLA2G4A | 0.012 |
| hsa04933:AGE-RAGE signaling pathway in diabetic complications | AKT1,CCND1,PRKCA | 0.0232 |
| hsa04024:cAMP signaling pathway | AKT1,PPARA,GABBR1 | 0.0232 |
| hsa04014:Ras signaling pathway | AKT1,PRKCA,PLA2G2A,PLA2G4A | 0.0318 |
| hsa04068:FoxO signaling pathway | AKT1,CCND1,S1PR1 | 0.0391 |
| hsa04371:Apelin signaling pathway | AKT1,CCND1,SPHK2 | 0.0408 |
| hsa04340:Hedgehog signaling pathway | SHH,CCND1 | 0.0416 |
| hsa04310:Wnt signaling pathway | CCND1,PRKCA,PPARA | 0.0468 |