Table 3.
Factors associated with acute ALBI-grade migration of the 531 BCLC-B HCC patients undergoing TACE.
| Factors | No. | Univariate | Multivariate | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | Model 4 | ||||||||
| OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | OR (95% CI) | p | ||
| Age (years), >70/≤70 | 265/266 | 1.209 (0.812–1.798) | 0.350 | - | |||||||
| Gender, Male/Female | 412/119 | 1.446 (0.872–2.398) | 0.153 | - | |||||||
| HBV vs. HCV † | 220/156 | 2.092 (1.263–3.465) | 0.004 | 2.046 (1.232–3.399) | 0.006 | 1.968 (1.178–3.288) | 0.010 | 1.882 (1.125–3.146) | 0.016 | 2.061 (1.243–3.416) | 0.005 |
| Alcoholic, Yes/No | 66/465 | 1.196 (0.668–2.141) | 0.547 | - | |||||||
| Cirrhosis, Yes/No | 379/152 | 0.710 (0.464–1.086) | 0.114 | - | |||||||
| PLT (K), ≤120/>120 | 196/335 | 0.557 (0.360–0.862) | 0.009 | 0.830 (0.491–1.403) | 0.487 | 0.911 (0.533–1.557) | 0.733 | 0.883 (0.516–1.511) | 0.650 | 0.848 (0.498–1.446) | 0.545 |
| ALT (IU/L), >40/≤40 | 306/225 | 1.218 (0.812–1.827) | 0.340 | - | |||||||
| AST (IU/L) ‡, >45/≤45 | 325/205 | 1.462 (0.960–2.228) | 0.077 | 1.302 (0.774–2.190) | 0.320 | 1.230 (0.728–2.077) | 0.439 | 1.209 (0.710–2.056) | 0.485 | 1.271 (0.751–2.151) | 0.372 |
| INR, >1.0/≤1.0 | 427/104 | 1.440 (0.844–2.456) | 0.181 | - | |||||||
| Tumor location Bilobar/Unilobar | 258/273 | 0.860 (0.578–1.280) | 0.457 | - | |||||||
| Tumor size, per cm | 531 | 1.133 (1.075–1.193) | <0.001 | - | |||||||
| Tumor number, ≥3/<3 | 269/262 | 0.739 (0.497–1.101) | 0.138 | - | |||||||
| Up-to-6, Out/In | 448/83 | 1.881 (1.003–3.527) | 0.049 | 2.031 (0.952–4.330) | 0.067 | - | - | - | - | - | - |
| Up-to-7, Out/In | 366/165 | 2.517 (1.534–4.129) | <0.001 | - | - | 2.838 (1.567–5.141) | 0.001 | - | - | - | - |
| Up-to-11, Out/In | 141/390 | 2.267 (1.484–3.463) | <0.001 | - | - | - | - | 1.836 (1.095–3.080) | 0.021 | - | - |
| Up-to-12, Out/In | 107/424 | 1.907 (1.204–3.023) | 0.006 | - | - | - | - | - | - | 1.625 (0.919–2.875) | 0.095 |
| AFP (ng/mL), >400/≤400 | 149/382 | 1.686 (1.104–2.574) | 0.016 | 1.260 (0.756–2.100) | 0.376 | 1.181 (0.705–1.979) | 0.528 | 1.266 (0.759–2.111) | 0.367 | 1.316 (0.792–2.185) | 0.289 |
† exclude 24 co-infection patients; ‡ One missing data; Abbreviations: ALBI, Albumin-Bilirubin; BCLC, Barcelona Clinic Liver Cancer; HCC, hepatocellular carcinoma; TACE, transarterial chemoembolization; OR, odds ratio; CI, confidence interval; HBV, hepatitis B virus; HCV, hepatitis C virus; PLT, platelet count; K, kilo; ALT, alanine transaminase; AST, aspartate aminotransferase; IU, international unit; INR, international normalized ratio; AFP, alpha-fetoprotein.