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Overview of the alveolar NLRP3 inflammasome activation on alveolar innate cells during M. tuberculosis infection. The host PRRs (TLR4) is activated by M. tuberculosis surface PAMPs stimulate the NF-kB transcriptional factor to transcribe IL1, IL18, and CASP4/11 that are processed by activation of the inflammasome complex through NLRP3 and CASP1. Image was created in BioRender.com (accessed on 23 August 2021).
