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Molecular mechanisms of endometrial cancer development.
| Endometrial Cancer Type | Molecular Factors/Genes | Changes in Function Leading to Endometrial Cancer |
|---|---|---|
| Type 1 | ||
| CTNNB1 | Mutation | |
| POLE | Mutation | |
| KRAS | Mutation | |
| PTEN | Loss | |
| AKT | Up-regulation | |
| PI3KSA | Up-regulation | |
| G1/S cell cycle phase | Progression | |
| Bcl-2 | Loss of down-regulation | |
| MLH1/MSH6 | Instability | |
| DNA | Mismatch | |
| Type 2 | ||
| TP53 | Mutation | |
| ERBB-2 (HER2/neu) | Overexpression | |
| p-16 | Inactivation | |
| E-cadherin | Reduction | |
