Table 1.
Enrichment analysis results. Table shows top 20 pathways enriched (FDR < 0.05) in the list of target genes. Fold enrichment (FE) values greater than 1 indicate that the pathway annotation is overrepresented in the experiment and less than 1 indicates that it is underrepresented.
| Panther Pathways 1 | Genes in Reference 2 | Genes in List 3 | FE 4 | FDR 5 |
|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor pathway (P06664) | 230 | 64 | 6.41 | 2.13 × 10−26 |
| CCKR signaling map (P06959) | 174 | 54 | 7.15 | 3.27 × 10−24 |
| Apoptosis signaling pathway (P00006) | 118 | 45 | 8.79 | 3.39 × 10−23 |
| p53 pathway feedback loops 2 (P04398) | 51 | 30 | 13.56 | 1.42 × 10−19 |
| Angiogenesis (P00005) | 173 | 47 | 6.26 | 2.69 × 10−19 |
| p53 pathway (P00059) | 87 | 33 | 8.74 | 4.09 × 10−17 |
| EGF receptor signaling pathway (P00018) | 134 | 39 | 6.71 | 5.68 × 10−17 |
| Interleukin signaling pathway (P00036) | 89 | 32 | 8.29 | 3.72 × 10−16 |
| Ras pathway (P04393) | 74 | 29 | 9.03 | 1.69 × 10−15 |
| Inflammation mediated by chemokine and cytokine signaling pathway (P00031) | 260 | 50 | 4.43 | 2.27 × 10−15 |
| PDGF signaling pathway (P00047) | 148 | 36 | 5.61 | 8.73 × 10−14 |
| TGF-beta signaling pathway (P00052) | 97 | 28 | 6.65 | 2.46 × 10−12 |
1 Pathway name and code in parentheses. 2 Number of genes in the reference that are associated with a given pathway. 3 Number of genes in the input list associated with a given pathway. 4 FE: Fold enrichment, the number in the input list divided by the expected number. 5 FDR: Benjamini–Hochberg corrected p-values.