Table 1.

Effects of different chemotherapeutic regimens on intestinal microbiota in animal experiments.

Chemotherapy Regimen	Effects on Gut Microbiota	Reference
	Diversity of the microbiota community↓; Bifidobacterium, Lactobacillus↓; Bacteroides, Escherichia, Helicobacter, Parabacteroides↑.	[27]
	E. coli↑; Lactobacillus spp↓.	[7]
	Lactobacillus, Prevotella↓; Bacteroides, Escherichia↑.	[28]
	Total bacteria abundance↓; Lactobacillus, Clostridium cluster III and XIVa↓; Enterococcus spp., Lachnospiraceae↑.	[29]
	Firmicutes, Actinobacteria, Tenericutes↓; Bacteroidetes, Proteobacteria↑.	[30]
	Firmicutes, Verrucomicrobia↑; Bacteroidetes↓.	[31]
	Diversity of the microbiota community↓; Ruminococcaceae, Eisenbergiella and Marvinbryantia↑.	[32]
	On Day6 and Day14, diversity of microbiota community↓; Ruminococcaceae, Bacteroides fragilis ↓; Lachnospiraceae↑.	[33]
	Firmicutes, Tenericutes↑; Bacteroidetes, Cyanobacteria↓.	[34]
	Firmicutes, Proteobacteria↑; Bacteroidetes, Lactobacillus, Bifidobacterium↓.	[35]
	E. coli, Pseudomonas, Enterococcus↑.	[36]
	Diversity of the microbiota community↓; Bacteroidetes, Actinobacteria↓; Fusobacteria, Proteobacteria↑.	[37]
	Bacteria were detected in mesenteric lymph node and spleen.	[38]
	The total bacteria number on Day2↓; Lactobacillus on Day2, Bifidobacterium on Day2 and Day6↓.	[39]
	Richness of microbiota↓; Bacteroidetes and Firmicutes not changed; Proteobacteria, Porphyromonadaceae, Mogibacteriaceae↑; Rikenellaceae↓.	[40]
	Bacteroidetes, Firmicutes↓; Verrucomicrobia, Proteobacteria, E. coli↑; Akkermansia muciniphila and Peptoclostridium difficile were detected.	[41]
	Bacteroidetes↓; Protebacteria↑.	[42]

↑, increases; ↓, decreases.