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. 2021 Aug 24;22(17):9113. doi: 10.3390/ijms22179113

Figure 7.

Figure 7

Schematic diagram of ssc-circINHA-001 affecting inhibin and activin balance through competitively binding miR-214-5p/miR-7144-3p/miR-9830-5p in pig GCs. The competitive splicing of circINHA-001 reduced the expression of INHA mRNA and α-subunit. Following exportation to the cytoplasm, circINHA can function by competing with INHBA mRNA for miR-214-5p/miR-7144-3p/miR-9830-5p interactions, thereby alleviating the posttranscriptional repression of INHBA and thus enhancing βA-subunit. The balance of hormone production may, therefore, tilt toward activin from inhibin and finally induce GC resistance to apoptosis and follicular atresia.