Figure 5.

Stratification of the possibilities of overall survival (OS) and progression-free survival (PFS) by Overlap66 and Overlap21. (A,B) Cutoff points were determined by Maximally Selected Rank Statistics for the risk scores of Overlap66 (see Figure S9) and Overlap21. Kaplan Meier curves for OS (A) and PFS (B) are constructed, using the R survival package, with the populations at risk in the indicated follow-up period included. Statistical analyses were performed using logrank test. The median months of OS and PFS are indicated. Time-dependent ROC (receiver operating characteristic; tROC) curves were generated using the R timeROC package; time-dependent area under the curve (AUC) values for the indicated multigene sets are shown. (C,D) ROC and precision-recall (PR) curves for Overlap66 and Overlap21 in predicting OS and PFS possibilities were produced using the R PRROC.