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. 2021 Aug 28;22(17):9322. doi: 10.3390/ijms22179322

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Pathways and protein–protein interactions regulated by the common AML/T2D-related genes. (A). Pathways enriched upon gene set analysis of 86 AML/T2D common susceptibility genes plus the seven eGenes affected by the five common AML/T2D susceptibility genes and their proxies, using KEGG database. (B). Protein–protein interaction (PPI) network developed upon processing the set in the STRING database. Different genes/proteins involved in different (one or more) pathways are designated by the differently colored nodes. Edges represent protein–protein associations—either known interactions, predicted interactions or other associations.