Table 3.
Summary of the proxy SNPs (R2 ≥ 0.8) for each common AML/T2D susceptibility SNP, along with their chromosomal location, correlated alleles and associated genes, as collected from LDLink tool [24] (May 2021).
| Proxy SNPs | Chr | Position | Alleles | R2 | Correlated Alleles | Associated Genes | |
|---|---|---|---|---|---|---|---|
| rs11709077 | rs17036160 | 3 | 12329783 | (C/T) | 0.9844 | G = C,A = T | PPARG |
| rs2012444 | 3 | 12375956 | (C/T) | 0.9751 | G = C,A = T | ||
| rs13064760 | 3 | 12369401 | (C/T) | 0.9751 | G = C,A = T | ||
| rs150732434 | 3 | 12360884 | (G/-) | 0.9751 | G = G,A = - | ||
| rs13083375 | 3 | 12365308 | (G/T) | 0.972 | G = G,A = T | ||
| rs35000407 | 3 | 12351521 | (T/G) | 0.9539 | G = T,A = G | ||
| rs4684847 | 3 | 12386337 | (C/T) | 0.9391 | G = C,A = T | ||
| rs11712037 | 3 | 12344730 | (C/G) | 0.9379 | G = C,A = G | ||
| rs35788455 | 3 | 12388908 | (TTG/-) | 0.9362 | G = TTG,A = - | ||
| rs1801282 | 3 | 12393125 | (C/G) | 0.9334 | G = C,A = G | ||
| rs71304101 | 3 | 12396913 | (G/A) | 0.9083 | G = G,A = A | ||
| rs35408322 | 3 | 12360357 | (-/T) | 0.9021 | G = -,A = T | ||
| rs1801282 | rs4684847 | 3 | 12386337 | (C/T) | 0.9939 | C = C,G = T | PPARG, TIMP4 |
| rs35788455 | 3 | 12388908 | (TTG/-) | 0.9908 | C = TTG,G = - | ||
| rs71304101 | 3 | 12396913 | (G/A) | 0.9613 | C = G,G = A | ||
| rs150732434 | 3 | 12360884 | (G/-) | 0.9573 | C = G,G = - | ||
| rs13064760 | 3 | 12369401 | (C/T) | 0.9573 | C = C,G = T | ||
| rs2012444 | 3 | 12375956 | (C/T) | 0.9573 | C = C,G = T | ||
| rs13083375 | 3 | 12365308 | (G/T) | 0.9543 | C = G,G = T | ||
| rs35000407 | 3 | 12351521 | (T/G) | 0.9365 | C = T,G = G | ||
| rs11709077 | 3 | 12336507 | (G/A) | 0.9334 | C = G,G = A | ||
| rs17036160 | 3 | 12329783 | (C/T) | 0.9183 | C = C,G = T | ||
| rs35408322 | 3 | 12360357 | (-/T) | 0.8855 | C = −,G = T | ||
| rs11712037 | 3 | 12344730 | (C/G) | 0.8806 | C = C,G = G | ||
| rs6685701 | rs4970486 | 1 | 26871669 | (C/T) | 0.9826 | A = C,G = T | RPS6KA1 |
| rs737465 | 1 | 26862939 | (T/C) | 0.9814 | A = T,G = C | ||
| rs11580180 | 1 | 26867453 | (A/G) | 0.9746 | A = A,G = G | ||
| rs2278978 | 1 | 26873245 | (A/G) | 0.9311 | A = A,G = G | ||
| rs4443935 | 1 | 26875433 | (A/G) | 0.9072 | A = A,G = G | ||
| rs10902750 | 1 | 26876245 | (G/T) | 0.9052 | A = G,G = T | ||
| rs389548 | 1 | 26891697 | (C/A) | 0.8777 | A = C,G = A | ||
| rs11108094 | rs11108087 | 12 | 95915763 | (A/G) | 0.8578 | C = A,A = G | USP44, METAP2 |
| rs61939481 | 12 | 95921998 | (T/C) | 0.8477 | C = T,A = C | ||
| rs143400372 | 12 | 95923620 | (-/A) | 0.8477 | C = -,A = A | ||
| rs11108086 | 12 | 95914758 | (T/C) | 0.8187 | C = T,A = C | ||
| rs79067108 | 12 | 95881761 | (CT/-) | 0.8141 | C = CT,A = - | ||
| rs11108070 | 12 | 95881787 | (T/A) | 0.8141 | C = T,A = A | ||
| rs12369757 | 12 | 95888603 | (G/A) | 0.8141 | C = G,A = A | ||
| rs11108072 | 12 | 95890218 | (T/C) | 0.8141 | C = T,A = C | ||
| rs10859889 | 12 | 95890413 | (A/T) | 0.8141 | C = A,A = T | ||
| rs11522874 | 12 | 95893609 | (G/A) | 0.8141 | C = G,A = A | ||
| rs61939476 | 12 | 95894581 | (A/C) | 0.8141 | C = A,A = C | ||
| rs11108076 | 12 | 95897348 | (G/A) | 0.8141 | C = G,A = A | ||
| rs11108079 | 12 | 95899173 | (G/A) | 0.8141 | C = G,A = A | ||
| rs12146719 | 12 | 95901434 | (C/A) | 0.8141 | C = C,A = A | ||
| rs61939479 | 12 | 95905364 | (C/T) | 0.8141 | C = C,A = T | ||
| rs2305293 | 12 | 95879734 | (C/T) | 0.8095 | C = C,A = T | ||
| rs11519597 | 12 | 95894247 | (T/C) | 0.8095 | C = T,A = C | ||
| rs61939477 | 12 | 95896692 | (A/G) | 0.8095 | C = A,A = G | ||
| rs4762563 | 12 | 95915341 | (G/C) | 0.805 | C = G,A = C | ||
| rs7929543 | rs11603576 | 11 | 49344126 | (G/A) | 0.9947 | A = G,C = A | FOLH1, AC118942.1 |
| rs10839264 | 11 | 49356806 | (C/T) | 0.9511 | A = C,C = T | ||
| rs76218798 | 11 | 49356186 | (T/C) | 0.9366 | A = T,C = C | ||
| rs11607791 | 11 | 49358347 | (T/C) | 0.9339 | A = T,C = C | ||
| rs1880436 | 11 | 49344775 | (A/G) | 0.92 | A = A,C = G | ||
| rs148517532 | 11 | 49332611 | (A/G) | 0.9188 | A = A,C = G | ||
| rs144550850 | 11 | 49366641 | (T/C) | 0.9175 | A = T,C = C | ||
| rs1843629 | 11 | 49319195 | (G/A) | 0.9161 | A = G,C = A | ||
| rs75781920 | 11 | 49371482 | (T/G) | 0.9152 | A = T,C = G | ||
| rs76427006 | 11 | 49375021 | (T/A) | 0.9149 | A = T,C = A | ||
| rs7932396 | 11 | 49299282 | (A/G) | 0.9112 | A = A,C = G | ||
| rs1843628 | 11 | 49323039 | (A/G) | 0.9033 | A = A,C = G | ||
| rs7939300 | 11 | 49311134 | (C/A) | 0.8985 | A = C,C = A | ||
| rs7939316 | 11 | 49311208 | (A/G) | 0.8985 | A = A,C = G | ||
| rs11040313 | 11 | 49299786 | (A/G) | 0.8915 | A = A,C = G | ||
| rs11040291 | 11 | 49248150 | (C/T) | 0.8898 | A = C,C = T | ||
| rs61350355 | 11 | 49292311 | (G/A) | 0.8757 | A = G,C = A | ||
| rs16906190 | 11 | 49203487 | (A/G) | 0.8709 | A = A,C = G | ||
| rs11040354 | 11 | 49409798 | (G/A) | 0.847 | A = G,C = A | ||
| rs10839244 | 11 | 49263085 | (A/G) | 0.8406 | A = A,C = G | ||
| rs74380550 | 11 | 49236977 | (C/T) | 0.8301 | A = C,C = T | ||
| rs59386222 | 11 | 49235409 | (G/A) | 0.8288 | A = G,C = A | ||
| rs4091958 | 11 | 49234514 | (T/C) | 0.8286 | A = T,C = C | ||
| rs11040365 | 11 | 49448078 | (C/A) | 0.826 | A = C,C = A | ||
| rs10839237 | 11 | 49215635 | (C/T) | 0.8187 | A = C,C = T | ||
| rs76002284 | 11 | 49271829 | (A/G) | 0.8145 | A = A,C = G | ||
| rs11040352 | 11 | 49395272 | (A/C) | 0.8039 | A = A,C = C |