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Uptake of selenoprotein P (SELENOP) and selenate in CNS. Selenoprotein P is imported into CNS via the ApoE-receptor LRP8 and is crucial for the synthesis of antioxidative selenoenzymes. Selenate is presumed to be imported by an anion carrier and is hypothesized to act as an activator of protein phosphatase 2 (PP2A), thereby reducing tau phosphorylation (see text). Selenate may also support selenoprotein synthesis.
