Table 1.
List of NFE2L2 transcript variants and encoded protein isoforms.
| mRNA | Protein | ||||||
|---|---|---|---|---|---|---|---|
| Transcript Variant | NCBI Reference Sequence | No of Base Pairs | Information | Isoform | NCBI Reference Sequence | No of Amino Acids | Information |
| 1 | NM_006164.5 | 2446 bp | The longest transcript variant encoding the longest isoform. |
1 | NP_006155.2 | 605 aa | The isoform has the canonical sequence. |
| 2 | NM_001145412.3 | 2988 bp | Uses an alternate promoter, 5’ UTR and a downstream start codon vs. var. 1. It has a shorter N-terminus than isoform 1. |
2 | NP_001138884.1 | 589 aa | Protein lacks the Keap1 interaction domain, resulting in Nrf2 stabilization. Found in the lung and head-and-neck cancers. |
| 3 | NM_001145413.3 | 2967 bp | Uses an alternate promoter, 5’ UTR, downstream start codon, and an alternate in-frame splice site in the 3’ coding region vs. var. 1. It has a shorter N-terminus and is missing an internal segment than. isoform 1. |
3 | NP_001138885.1 | 582 aa | Protein lacks the Keap1 interaction domain, resulting in Nrf2 stabilization. |
| 4 | NM_001313900.1 | 2862 bp | Uses an alternate promoter, 5’ UTR and a downstream start codon vs. var. 1. It has a shorter N-terminus than isoform 1. | 2 | NP_001138884.1 | 589 aa | Protein lacks the Keap1 interaction domain, resulting in Nrf2 stabilization. Found in the lung and head-and-neck cancers. |
| 5 | NM_001313901.1 | 2954 bp | Uses an alternate promoter, 5’ UTR and a downstream start codon vs. var. 1. It has a shorter N-terminus than isoform 1. | 2 | NP_001138884.1 | 589 aa | Protein lacks the Keap1 interaction domain, resulting in Nrf2 stabilization. Found in the lung and head-and-neck cancers. |
| 6 | NM_001313902.1 | 2769 bp | Lacks an alternate in-frame exon in the 3’ coding region vs. var. 1. It is shorter than isoform 1. |
4 | NP_001300831.1 | 575 aa | Computationally mapped isoform. |
| 7 | NM_001313903.1 | 2640 bp | Uses an alternate in-frame splice site in the 3’ coding region vs. var. 1. It is shorter than isoform 1. | 5 | NP_001300832.1 | 532 aa | Computationally mapped isoform. |
| 8 | NM_001313904.1 | 2917 bp | Uses an alternate promoter, 5’ UTR and an alternate in-frame splice site in the 3’ coding region, vs. variant 1. It is shorter than isoform 1. |
6 | NP_001300833.1 | 505 aa | Computationally mapped isoform. |