| [85] |
Kesh et al. |
2020 |
T2D mice vs. control (both with pancreatic adenocarcinoma +/− chemotherapy) |
Bacteroides intestinalis and Lactobacillus murinus species were more abundant in the control group. Enterobacter cloacae and Bacteroides uniformis species were specifically expressed in the T2D group. Dysbiosis in the microbiota seen in animals with T2D associated with increased resistance to chemotherapy.
|
| [86] |
Yin et al. |
2020 |
T2D mice (induced by high-fat or high-sucrose-fat diet + STZ)
vs. control |
Bacteroidetes levels were reduced in high-fat diet-fed mice vs. high sucrose. Intestinal microbiota composition did not change after STZ, suggesting that the difference in metabolic phenotypes and gut microbiota was diet-related.
|
| [87] |
Grasset et al. |
2017 |
T2D obese mice (fed HFD/ high-carbohydrate diet) and T2D mice (fed HFD/carbohydrate-free diet) compared to control (on chow diet) |
Bacteroidales, Burkholderiales, Clostridiales, and TM7 (Saccharibacteria) orders were increased in T2D vs. control. Increased Porphyromonadaceae, Clostridiaceae, Peptostreptococcaceae, Burkolderiaceae, and TM7 families and reduced frequency of Lactobacillaceae in the T2D group was associated with
Glucagon-like peptide 1 (
GLP-1) resistance. The gut-brain axis is impaired in T2D mice, and this can prevent beta cell sensitivity to GLP-1. Eubiotic microbiota required for GLP-1 sensitivity.
|
| [88] |
Everard et al. |
2013 |
ob/ob mice and HFD-fed mice, with and without prebiotics vs. lean control mice |
The presence of Bacterium inversely correlated with body weight. Akkermansia (A) muciniphila is reduced in obese mice and mice with T2D. A. muciniphila administration reversed obesity-related metabolic disease, increased the levels of endocannabinoids, and controlled inflammation.
|
