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Mice null for the Inhibitor of DNA binding 4 (Id4) gene (Id4−/− mice) show a reduction in the magnitude of wheel activity and a shorter free-running period length. (a) Wheel revolutions and (b) circadian period length for wild-type (WT) (white) and Id4−/− (orange) mice. See Figure 2, Figure 3 and Figure 4 for representative locomotor activity records (actograms). *** p < 0.001.
