Figure 1.

Tumor-specific bioluminescent images in representative mice. Groups of NOD-SCID mice (N = 5, age of eight weeks) were inoculated with 3 × 10⁵ cells of metastatic human prostate cancer 22Rv1-M4 cells vs. mock control (PBS). Based on the housekeeping expression of the luciferase 2 (Luc2) reporter gene in the tumor cells, in vivo bioluminescent imaging of tumors was captured and quantified using an IVIS Lumina XRMS System weekly as marked.