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. 2021 Sep 10;12:501. doi: 10.1186/s13287-021-02570-9

Fig. 7.

Fig. 7

A model of the anti-hyperpigmentation of hAMSC-CM. Upon UV radiation, keratinocytes secrete α-MSH to induce MITF expression and promote melanogenesis in melanocyte. hAMSC-CM and hAMSCs-derived exosomes reduce excessive melanin deposition by suppressing melanogenesis and promoting melanosome degradation. Furthermore, exosomes-derived miR-181a-5p and miR-199a reduce MITF expression to suppress melanin content and regulating autophagy flux to promote melanosome degradation, respectively