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CD112R and CD112 structures. A. CD112R protein includes a single extracellular IgV domain, one transmembrane domain, and a long intracellular domain with an ITIM-like motif. B. CD112 protein is composed of an extracellular region with three Ig-like domains (a distal IgV domain and two IgC domains), a single transmembrane region, and a cytoplasmic tail possessed a conserved afadin-binding motif
