Fig. 2.

CD112R and CD112 expression in health and tumor microenvironment. (A) In normal human peripheral blood cell subsets, CD112R is predominantly expressed in NK cells and CD8⁺ T cells, but not in CD4⁺ T cells, DCs, neutrophils, monocytes and B cells. CD112R⁺CD8⁺ T cells are mainly detected in effector memory T (CD45RA⁻CCR7⁻) cell in phenotype, and rarely in naïve T (CD45RA⁺CCR7⁺) cells. (B) In mouse, CD112R are detectable in NK cells and NKT cells, but are barely detectable in CD4⁺ T cells and CD8⁺T cells. (C) In the tumor microenvironment, CD112R is expressed abundantly in NK cells, CD4⁺ T cells and CD8⁺ T cells. Meanwhile, CD112 was detectable primarily in DCs, tumor-associated macrophages (TAMs) or monocytes, and tumors cells