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. 2021 Sep 8;62(12):3. doi: 10.1167/iovs.62.12.3

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Figure 10. — Progression of anterior cortical cataract in Epha2-knockout mice on FVB:C57BL/6J mixed background.Epha2^+/+, Epha2^+/⁻, and Epha2⁻^/⁻ mice on FVB:C57BL/6J (50:50) mixed background were monitored for cataract development from 11 ± 3 weeks to 64 ± 3 weeks of age. (A) Mean cortical cataract grade in each genotype of mice at each time point is graphically represented. Epha2⁻^/⁻ mice developed severe cataract by 38 ± 3 weeks of age whereas Epha2^+/⁻ mice developed only moderate cataract by 64 ± 3 weeks of age. Epha2^+/+ mice presented with mild cataract up to 64 ± 3 weeks of age. The Mann Whitney U test P values from comparison with Epha2^+/+ mice are indicated. Error bars represent standard error of the mean. After an animal exhibited a cataract grade of 4 or 5, the same grade was attributed to subsequent time points for data analysis assuming no further increase in cataract severity. (B) The table shows Wilcoxon Signed Ranks test P values of comparison between time points indicating the effect of age on cataract progression in each genotype of mice. † Indicates likely artifact of anesthetic-induced cataract.