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. 2021 Sep 8;62(12):3. doi: 10.1167/iovs.62.12.3

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Figure 11. — Anterior cortical cataract developed in Epha2-knockout mice on FVB:C57BL/6J mixed background. Representative ophthalmic images of Epha2^+/+ (A, B, C) and Epha2^+/⁻ (D, E, F) mice at 18 ± 3, 38 ± 3 and 64 ± 3 weeks of age and Epha2⁻^/⁻ (G, H) mice at 18 ± 3 and 38 ± 3 weeks of age, on FVB:C57BL/6J (50:50) mixed background, are shown. No cataract was evident in Epha2^+/+, C, or in Epha2^+/−, F, mice up to 64 weeks of age. Epha2^−/− mice progressively developed severe ACC by 38 ± 3 weeks of age, H. The bottom right panel shows cross-section illumination images of the Epha2⁻^/⁻ and Epha2^+/⁻ eyes seen in panels H and F, respectively. Magnification, times 40.