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. 2021 Sep 8;62(12):3. doi: 10.1167/iovs.62.12.3

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Figure 13. — Comparison of progression of anterior cortical cataract between male and female Epha2-knockout mice on C57BL/6J and FVB:C57BL/6J mixed backgrounds. Anterior cortical cataract severity was compared between male (blue lines) and female (red lines) Epha2^+/⁻ and Epha2⁻^/⁻ mice on C57BL/6J and FVB:C57BL/6J (50:50) mixed genetic backgrounds. (A) Male and female Epha2^+/⁻ mice on C57BL/6J background showed similar progression of cataract from 11 ± 3 to 45 ± 3 weeks of age. (B) Female Epha2⁻^/⁻ mice on C57BL/6J background displayed milder cataract compared to male mice at 11 ± 3 weeks of age (P < 0.05) whereas both male and female mice exhibited similar severe cataracts at 18 ± 3 weeks of age that persisted subsequently. (C) Both male and female Epha2^+/⁻ mice on the mixed genetic background displayed mild cataract up to 45 ± 3 weeks of age. Male mice gradually developed moderately severe cataract by 64 ± 3 weeks of age whereas age-matched female mice exhibited significantly milder cataract up to that age (P < 0.01). (D) Male and female Epha2⁻^/⁻ mice on the mixed background exhibited similar rate of progression of cataract from 11 ± 3 to 64 ± 3 weeks of age. The P values from the Mann Whitney U test are indicated. Error bars represent standard error of the mean.