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. 2021 Sep 8;62(12):3. doi: 10.1167/iovs.62.12.3

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Figure 3. — Anterior cortical cataract developed in Epha2-knockout mice. Representative ophthalmic images of Epha2^+/+ (A, B, C) and Epha2^+/⁻ (D, E, F) mice at 11 ± 3, 18 ± 3, and 38 ± 3 weeks of age and Epha2⁻^/⁻ (G, H) mice at 11 ± 3 and 18 ± 3 weeks of age, on C57BL/6J background, are shown. Epha2⁻^/⁻ mice progressively developed severe ACC by 18 ± 3 weeks of age, panel H, and Epha2^+/⁻ mice by 38 ± 3 weeks of age, panel F. The bottom right panel shows cross-section illumination images of cortical cataracts seen in panels H and F. Lenses of Epha2^+/+ mice remained relatively clear up to 38 ± 3 weeks of age, panel C, and later (not shown). Magnification, times 40.