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. 2021 Sep 8;62(12):3. doi: 10.1167/iovs.62.12.3

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Figure 6. — β-Catenin labeling showing breakdown of lens architecture in Epha2-knockout mouse lenses. Representative confocal microscopy images of sections of lenses of 18-week-old Epha2^+/+ (A), Epha2^+/⁻ (B), and Epha2⁻^/⁻ (C) and 45-week-old Epha2^+/+ (D) and Epha2^+/⁻ (E) mice on C57BL/6J background immunolabeled with mouse anti-β-catenin antibody (green) and DAPI (blue) to stain the nuclei are shown. Similar to N-cadherin labeling, β-catenin labeling delineated meridional rows of fiber cells in 18, A, and 45-week-old Epha2^+/+, D, and 18-week-old Epha2^+/−, B, lenses. In contrast, gross disorganization of fiber cells in 18-week-old Epha2^−/−, C, and 45-week-old Epha2^+/−, E, lenses was observed. Sections probed with mouse IgG (negative control) revealed little or no non-specific labeling (F). Scale-bars 20 µm.