Table 3.
Summary of meta-analytical data concerning cerebrospinal fluid cytokine levels in schizophrenia patients as compared to healthy controls.
| Marker | Miller et al. (2011) | Wang et al. (2018) | Gallego et al. (2018) | Orlovska-waast et al. (2019) | ||||
|---|---|---|---|---|---|---|---|---|
| Alt. | nS (nP) | Alt. | nS (nP) | Alt. | nS (nP) | Alt. | nS (nP) | |
| IL-1α | NA | 0 (0) | — | 2 (70) | NA | 0 (0) | — | 3 (72) |
| IL-1β | ↓ | 2 (13) | ↑ | 3 (57) | — | 4 (56) | — | 2 (40) |
| IL-2 | — | 4 (100) | — | 4 (114) | — | 4 (121) | — | 3 (97) |
| sIL-2R | NA | 0 (0) | ↓ | 2 (19) | NA | 0 (0) | NA | 0 (0) |
| IL-6 | — | 2 (42) | ↑ | 7 (244) | ↑ | 8 (256) | ↑ | 7 (230) |
| IL-8 | NA | 0 (0) | ↑ | 3 (112) | ↑ | 4 (105) | ↑ | 3 (95) |
| IL-12 | — | 2 (40) | NA | 0 (0) | NA | 0 (0) | NA | 0 (0) |
Alt.—alteration, nS—number of studies, nP—number of patients, NA—data not available, ——not alternated, ↑—elevated levels, ↓—reduced levels.