Table 3.

Associations and predictive value of change in brain volume measures over change in cognitive performance at two year follow-up in EOP (final prediction models for significant backwards regression analyses are displayed—see Methods).

DV *: CHANGE IN WORKING MEMORY OVER TIME
PREDICTORS: Change in Frontal Left GM Volume, age, months of inter-scan interval and interscan ICV change.
Model Summary	R	R2	Adjusted R2	Standard Error of the Estimate
	0.550	0.303	0.256	1.039
Model 4	B	Standard Error	Beta	t	p
Change in Frontal Left GM Volume	0.096	0.034	0.441	2.854	0.008
Age	0.027	0.010	0.412	2.666	0.012
PREDICTORS: Change in Frontal Right GM Volume, age, months of inter-scan interval and interscan ICV change.
Model Summary	R	R2	Adjusted R2	Standard Error of the Estimate
	0.523	0.274	0.225	1.061
Model 4	B	Standard Error	Beta	t	p
Change in Frontal Right GM Volume	0.089	0.035	0.400	2.570	0.015
Age	0.023	0.010	0.347	2.230	0.033
PREDICTORS: Change in Parietal Left GM Volume, age, months of inter-scan interval and interscan ICV change.
Model Summary	R	R2	Adjusted R2	Standard Error of the Estimate
	0.556	0.309	0.263	1.035
Model 4	B	Standard Error	Beta	t	p
Change in Parietal Left GM Volume	0.119	0.041	0.451	2.910	0.007
Age	0.028	0.010	0.426	2.752	0.010
PREDICTORS: Change in Parietal Right GM Volume, age, months of inter-scan interval and interscan ICV change.
Model Summary	R	R2	Adjusted R2	Standard Error of the Estimate
	0.523	0.274	0.225	1.061
Model 4	B	Standard Error	Beta	t	p
Change in Parietal Right GM Volume	0.125	0.049	0.403	2.571	0.015
Age	0.025	0.010	0.389	2.480	0.019
FINAL MODEL. PREDICTORS: Change in Frontal Left GM Volume, Change in Frontal Right GM Volume, Change in Parietal Left GM Volume, Change in Parietal Right GM Volume, age.
Model Summary	R	R2	Adjusted R2	Standard Error of the Estimate
	0.554	0.318	0.272	1.028
Model 4	B	Standard Error	Beta	t	p
Change in Frontal Left GM Volume	0.107	0.034	0.490	3.131	0.004
Age	0.362	0.129	0.441	2.815	0.009

* Dependent variable (DV), gray matter (GM).