Table 2.
The influence of diabetic state on relative wall thickness, left ventricular mass index, and phenotypes of left ventricular geometry.
| A. Diabetic State and Continuous Traits of Left Ventricular Mass | ||||||||
|---|---|---|---|---|---|---|---|---|
| Relative Wall Thickness | Left Ventricular Mass Index (g/m2.7) | |||||||
| Model 1: Age, Sex | Model 2: Add. Traditional CVRF |
Model 1: Age, Sex | Model 2: Add. Traditional CVRF | |||||
| β (95% CI) | p-Value | β (95% CI) | p-Value | β (95% CI) | p-Value | β (95% CI) | p-Value | |
| Prediabetes vs. euglycemia | −0.0072 (−0.010; −0.004) |
<0.0001 | −0.0111 (−0.014; −0.008) |
<0.0001 | 1.81 (1.44; 2.18) |
<0.0001 | 0.784 (0.43; 1.14) |
<0.0001 |
| Type 2 diabetes vs. euglycemia | 0.0104 (0.0055; 0.0152) |
<0.0001 | −0.000008 (−0.005; 0.005) |
1.0 | 5.78 (5.19; 6.36) |
<0.0001 | 2.48 (1.91; 3.05) |
<0.0001 |
| B. Diabetic State and Phenotypes of LV Geometry | ||||||||
| LV Hypertrophy | Concentric Remodeling | Concentric Hypertrophy | Eccentric Hypertrophy | |||||
| PR (95% CI) | p-Value | PR (95% CI) | p-Value | PR (95% CI) | p-Value | PR (95% CI) | p-Value | |
| Prediabetes vs. euglycemia | 1.093 (0.988; 1.208) |
0.084 | 0.829 (0.785; 0.874) |
<0.0001 | 0.918 (0.805; 1.047) |
0.2 | 1.103 (0.942; 1.290) |
0.22 |
| Type 2 diabetes vs. euglycemia | 1.219 (1.070; 1.388) |
0.0029 | 0.957 (0.888; 1.031) |
0.25 | 1.065 (0.898; 1.264) |
0.47 | 1.410 (1.147, 1.733) |
0.0011 |
A. Multiple linear regression models for investigation of the association between diabetic state (independent variable) on relative wall thickness and left ventricular mass index as dependent variables. Model 1 adjusted for age and sex. Model 2 adjusted for age, sex, hypertension, dyslipidemia, obesity, smoking, FH of MI/stroke. B. Robust Poisson regression models for assessment of the influence of diabetic state on phenotypes of LV hypertrophy adjusted for age, sex, hypertension, dyslipidemia, obesity, smoking, FH of MI/Stroke, log(CRP (mg/L)), E/E’, and EF. CI, confidence interval. CRP, C-reactive protein. CVRF, cardiovascular risk factors. FH of MI/stroke, family history of myocardial infarction or stroke. LV, left ventricle. PR, prevalence ratio. vs., versus.