Table 2.
Comparisons at baseline and 6 months.
| Control (n = 24) |
Spironolactone (n = 25) |
p-Value | ||
|---|---|---|---|---|
| Systolic BP (mmHg) | Baseline | 131 ± 6 | 131 ± 6 | 0.965 |
| 6 months | 131 ± 6 | 129 ± 5 | 0.191 | |
| Diastolic BP (mmHg) | Baseline | 77 ± 7 | 77 ± 5 | 0.980 |
| 6 months | 76 ± 6 | 77 ± 5 | 0.807 | |
| Potassium (mmol/L) | Baseline | 4.1 ± 0.3 | 4.3 ± 0.4 | 0.213 |
| 6 months | 4.3 ± 0.4 | 4.5 ± 0.4 * | 0.010 | |
| QOL score | Baseline | 27 ± 22 | 30 ± 20 | 0.623 |
| 6 months | 24 ± 22 | 22 ± 20 * | 0.818 | |
| NT-proBNP (pg/mL) | Baseline | 229 ± 281 | 337 ± 653 | 0.459 |
| 6 months | 182 ± 173 | 183 ± 213 | 0.994 | |
| LA diameter (mm) | Baseline | 37 ± 6 | 36 ± 5 | 0.498 |
| 6 months | 37 ± 5 | 36 ± 4 | 0.212 | |
| LAVI (ml/m2) | Baseline | 24.8 ± 9.2 | 23.1 ± 9.5 | 0.548 |
| 6 months | 22.9 ± 6.1 | 21.6 ± 6.1 | 0.472 | |
| IVS (mm) | Baseline | 11.3 ± 1.8 | 11.5 ± 1.9 | 0.682 |
| 6 months | 11.9 ± 1.7 | 11.9 ± 1.3 | 0.953 | |
| PW (mm) | Baseline | 11.4 ± 1.9 | 11.7 ± 1.9 | 0.564 |
| 6 months | 11.5 ± 1.4 | 11.1 ± 1.3 | 0.323 | |
| LVEDD (mm) | Baseline | 44.5 ± 5.0 | 46.6 ± 4.1 | 0.116 |
| 6 months | 43.9 ± 5.3 | 45.0 ± 4.5 | 0.445 | |
| LVESD (mm) | Baseline | 28.2 ± 4.6 | 29.7 ± 3.6 | 0.223 |
| 6 months | 28.0 ± 4.2 | 28.3 ± 3.8 | 0.776 | |
| RWT | Baseline | 0.52 ± 0.10 | 0.50 ± 0.08 | 0.519 |
| 6 months | 0.54 ± 0.07 | 0.52 ± 0.05 | 0.349 | |
| LVM/Ht2.7 (g/m2.7) | Baseline | 60.5 ± 17.5 | 65.9 ± 20.1 | 0.317 |
| 6 months | 62.9 ± 19.2 | 62.6 ± 14.2 | 0.944 | |
| LVEF (%) | Baseline | 67 ± 7 | 66 ± 6 | 0.542 |
| 6 months | 66 ± 5 | 67 ± 7 | 0.684 | |
| Mitral E/A | Baseline | 0.99 ± 0.23 | 1.02 ± 0.34 | 0.708 |
| 6 months | 0.95 ± 0.32 | 0.86 ± 0.23 * | 0.318 | |
| E flow DT (ms) | Baseline | 234 ± 50 | 214 ± 37 | 0.135 |
| 6 months | 230 ± 56 | 230 ± 53 | 0.958 | |
| IVRT (ms) | Baseline | 99 ± 21 | 100 ± 30 | 0.891 |
| 6 months | 92 ± 17 | 95 ± 20 | 0.629 | |
| Mitral Ea (cm/s) | Baseline | 7.7 ± 1.5 | 8.0 ± 2.2 | 0.583 |
| 6 months | 7.6 ± 2.4 | 9.0 ± 2.4 * | 0.063 | |
| Mitral E/Ea | Baseline | 9.7 ± 1.1 | 10.6 ± 2.7 | 0.158 |
| 6 months | 10.4 ± 3.5 | 8.7 ± 3.7 * | 0.096 |
BP, blood pressure; DT, deceleration time; Ea, annular early diastolic velocity; Ht, height; IVRT, isovolumic relaxation time; IVS, interventricular septal wall thickness; LA, left atrial; LAVI, left atrial volume index; LVEDD, left ventricular end-diastole dimension; LVEF, left ventricular ejection fraction; LVESD, left ventricular end-systole dimension; LVM, left ventricular mass; NT-proBNP, N-terminal pro–brain natriuretic peptide; PW, posterior wall thickness; QOL, quality of life; RWT, relative wall thickness. * p < 0.05, baseline vs. 6-months by paired t-test.