FIGURE 1.

Processing pipeline to measure the exchange time ($T_{\mathit{ex}}^w$) as an index of blood–brain barrier permeability to water using control data to determine extravascular tissue T₂ (T2_EV), multiple‐echo‐time (multi‐TE) arterial spin‐labeling (ASL) data to determine intravascular/extravascular ASL signal intensities (ΔM _IV/ΔM _EV), intravascular T₂ (T2_IV) and tissue transit time (δ), and multi‐TI (inflow time) ASL data to determine arterial transit time (δ_a ). Dotted lines indicate parameters with results for the individual animals and solid lines indicate parameters with result that is shared across the group. Adapted from Ohene et al, 2019¹⁹