Table 2.
Discriminatory ability and cut-off values of circulating biomarkers by ROC curve analysis distinguishing IPF from controls.
| KL-6 | SP-D | MMP-7 | CA19-9 | CA-125 | CCL18 | |
|---|---|---|---|---|---|---|
| AUC | 0.8589 | 0.9089 | 0.8946 | 0.6893 | 0.7723 | 0.7232 |
| 95% CI | 0.7430–0.9749 | 0.8196–0.9983 | 0.8011–0.9882 | 0.5341–0.8445 | 0.6355–0.9091 | 0.5750–0.8715 |
| p-value | <0.0001 | <0.0001 | <0.0001 | 0.0266 | 0.0014 | 0.0089 |
| Cut-off value | 673.95 U/mL | 121.80 ng/mL | 5.15 ng.mL | 11.50 U/mL | 4.55 U/mL | 242.05 ng/mL |
| Sensitivity | 82.14% | 100.00% | 78.6% | 67.86% | 64.29% | 82.14% |
| Specificity | 85.00% | 75.00% | 90.00% | 75.00% | 90.00% | 60.00% |
Abbreviations: ROC—receiver operating characteristic, KL-6—Krebs von den Lungen-6, SP-D—surfactant protein D, MMP-7—matrix metalloproteinase 7, CA19-9—cancer antigen 19-9, CA-125—cancer antigen 125, CCL18—chemokine (C-C motif) ligand 18, AUC—area under ROC curve, CI—confidence interval.