Figure 4.

Effects of ACE inhibitor use, and ARB use on the expression of SARS-CoV-2 receptor (ACE2) in human lung tissue. Superimposed box plots show median (IQR). p values are from robust linear models, adjusted for current smoking status. ACE inhibitor use was associated with significantly lower ACE2 expression, whereas ARB was not. Abbreviations: ACE, angiotensin-converting enzyme; ARB, angiotensin II receptor blocker; CPM, counts per million; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 [89].