Table 1.
Allele and genotype distribution for the NOD2 c.802C>T (p.P268S, rs2066842) variant.
| c.802C>T (p.P268S) rs2066842 |
Genotypes n (%) |
Alleles n (%) |
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|---|---|---|---|---|---|---|
| Group | n | TT | CT | CC | T | C |
| IBD whole group * | 556 | 89 (16.0%) | 221 (39.8%) | 246 (44.2%) | 399 (35.9%) | 713 (64.1%) |
| UC adults | 189 | 13 (6.9%) | 62 (32.8%) | 114 (60.3%) | 88 (23.3%) | 290 (76.7%) |
| UC adult women | 78 | 4 (5.1%) | 27 (34.6%) | 47 (60.3%) | 35 (22.4%) | 121 (77.6%) |
| UC adult men | 111 | 9 (8.1%) | 35 (31.5%) | 67 (60.4%) | 53 (23.9%) | 169 (76.1%) |
| UC children | 65 | 5 (7.7%) | 34 (52.3%) | 26 (40%) | 44 (33.8%) | 86 (66.2%) |
| UC girls | 28 | 1 (3.6%) | 11 (39.3%) | 16 (57.1%) | 13 (23.2%) | 43 (76.8%) |
| UC boys | 37 | 4 (10.8%) | 23 (62.1%) | 10 (27.1%) | 31 (41.9%) | 43 (58.1%) |
| UC whole group | 254 | 18 (7.1%) | 96 (37.8%) | 140 (55.1%) | 132 (26.0%) | 376 (74.0%) |
| CD adults * | 217 | 50 (23.1%) | 91 (41.9%) | 76 (35%) | 191 (44.1%) | 243 (55.9%) |
| CD adult women | 117 | 24 (20.5%) | 54 (46.2%) | 39 (33.3%) | 102 (43.6%) | 132 (56.4%) |
| CD adult men * | 100 | 26 (26%) | 37 (37%) | 37 (37%) | 89 (44.5%) | 111 (55.5%) |
| CD children | 85 | 21 (24.7%) | 34 (40%) | 30 (35.3%) | 76 (43.7%) | 98 (56.3%) |
| CD girls | 41 | 8 (19.5%) | 18 (43.9%) | 15 (36.6%) | 34 (41.5%) | 48 (58.5%) |
| CD boys | 44 | 13 (29.5%) | 16 (36.4%) | 15 (34.1%) | 42 (47.2%) | 47 (52.8%) |
| CD whole group * | 302 | 71 (23.5%) | 125 (41.4%) | 106 (35.1%) | 267 (44.2%) | 337 (55.8%) |
| Controls | 598 | 52 (8.8%) | 250 (42.5%) | 287 (48.7%) | 354 (30.1%) | 824 (69.9%) |
| (TT) vs. (CC) OR 95% CI p-value |
(TC) vs. (CC) OR 95% CI p-value |
(TT) + (TC) vs. (CC) OR 95% CI p-value |
(T) vs. (C) OR 95% CI p-value |
|||
| IBD whole group vs. controls |
OR = 2.00
CI = (1.36–2.93) p < 0.001 |
OR = 1.03 CI = (0.80–1.32) p = 0.808 |
OR = 1.20 CI = (0.95–1.51) p = 0.129 |
OR = 1.30
CI = (1.09–1.55) p = 0.003 |
||
| UC adults vs. controls | OR = 0.63 CI = (0.33–1.20) p = 0.157 |
OR = 0.62
CI = (0.44–0.89) p = 0.009 |
OR = 0.63
CI = (0.45–0.87) p = 0.006 |
OR = 0.71
CI = (0.54–0.92) p = 0.011 |
||
| UC children vs. controls | OR = 1.06 CI = (0.39–2.89) p = 0.907 |
OR = 1.50 CI = (0.88–2.57) p = 0.137 |
OR = 1.43 CI = (0.85–2.40) p = 0.181 |
OR = 1.19 CI = (0.81–1.75) p = 0.372 |
||
| UC adults vs. UC children | OR = 0.57 CI = (0.18–1.71) p = 0.311 |
OR = 0.47
CI = (0.26–0.84) p = 0.009 |
OR = 0.48
CI = (0.27–0.84) p = 0.010 |
OR = 0.62 CI = (0.40–0.95) p = 0.026 |
||
| UC women vs. UC men | OR = 0.62 CI = (0.18–2.13) p = 0.445 |
OR = 1.10 CI = (0.59–2.06) p = 0.766 |
OR = 1.00 CI = (0.56–1.82) p = 0.989 |
OR = 0.91 CI = (0.56–1.47) p = 0.695 |
||
| UC girls vs. UC boys | OR = 0.16 CI = (0.01–1.60) p = 0.087 |
OR = 0.30
CI = (0.10–0.87) p = 0.024 |
OR = 0.28
CI = (0.10–0.79) p = 0.014 |
OR = 0.42 CI = (0.19–0.90) p = 0.025 |
||
| UC whole group vs. controls | OR = 1.13 CI = (0.53–2.40) p = 0.755 |
OR = 1.26 CI = (0.84–1.89) p = 0.260 |
OR = 1.24 CI = (0.85–1.81) p = 0.274 |
OR = 1.16 CI = (0.85–1.58) p = 0.357 |
||
| CD adults vs. controls |
OR = 3.63
CI = (2.28–5.77) p < 0.001 |
OR = 1.38 CI = (0.97–1.95) p = 0.073 |
OR = 1.76
CI = (1.28–2.43) p < 0.001 |
OR = 1.83
CI = (1.46–2.29) p < 0.001 |
||
| CD children vs. controls |
OR = 3.86
CI = (2.05–7.26) p < 0.001 |
OR = 1.30 CI = (0.77–2.19) p = 0.320 |
OR = 1.74
CI = (1.09–2.80) p = 0.020 |
OR = 1.88
CI = (1.36–2.61) p < 0.001 |
||
| CD adults vs. UC children | OR = 0.94 CI = (0.48–1.82) p = 0.854 |
OR = 1.06 CI = (0.59–1.88) p = 0.852 |
OR = 1.01 CI = (0.60–1.71) p = 0.965 |
OR = 0.97 CI = (0.68–1.39) p = 0.876 |
||
| CD women vs. CD men | OR = 0.87 CI = (0.43–1.79) p = 0.715 |
OR = 1.39 CI = (0.75–2.56) p = 0.299 |
OR = 1.18 CI = (0.67–2.05) p = 0.573 |
OR = 0.96 CI = (0.66–1.41) p = 0.849 |
||
| CD girls vs. CD boys | OR = 0.61 CI = (0.19–1.91) p = 0.400 |
OR = 1.13 CI = (0.42–3.01) p = 0.814 |
OR = 0.90 CI = (0.37–2.18) p = 0.810 |
OR = 0.77 CI = (0.42–1.42) p = 0.411 |
||
| CD whole group vs. controls |
OR = 3.70
CI = (2.43–5.63) p < 0.001 |
OR = 1.35 CI = (0.99–1.85) p = 0.055 |
OR = 1.76
CI = (1.32–2.34) p < 0.001 |
OR = 1.84
CI = (1.50–2.26) p < 0.001 |
||
| CD whole group vs. UC whole group |
OR = 5.21
CI = (2.93–9.26) p < 0.001 |
OR = 1.72
CI = (1.19–2.48) p = 0.004 |
OR = 2.27
CI = (1.61–3.20) p < 0.001 |
OR = 2.26
CI = (1.75–2.91) p < 0.001 |
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Statistically significant results are marked in bold; *: deviation from HWE. IBD, inflammatory bowel disease; UC, ulcerative colitis; CD, Crohn’s disease; OR, odds ratio; CI, confidence interval.