Table 2.
Allele and genotype distribution for the NOD2 c.2104C>T (p.R702W, rs2066844) variant.
| c.2104C>T (p.R702W) rs2066844 |
Genotypes n (%) |
Alleles n (%) |
||||
|---|---|---|---|---|---|---|
| Group | n | TT | TC | CC | T | C |
| IBD whole group | 575 | n.o. | 50 (8.7%) | 525 (91.3%) | 50 (4.4%) | 1100 (95.6%) |
| UC adults | 210 | n.o. | 5 (2.4%) | 204 (97.6%) | 5 (1.2%) | 413 (98.8%) |
| UC adult women | 98 | n.o. | 1 (1.0%) | 96 (99.0%) | 1 (0.5%) | 193 (99.5%) |
| UC adult men | 112 | n.o. | 4 (3.6%) | 108 (96.4%) | 4 (1.8%) | 220 (98.2%) |
| UC children | 65 | n.o. | 4 (6.2%) | 61 (93.8%) | 4 (3.1%) | 126 (96.9%) |
| UC girls | 28 | n.o. | 2 (7.2%) | 26 (92.8%) | 2 (3.6%) | 54 (96.4%) |
| UC boys | 37 | n.o. | 2 (5.4%) | 35 (94.6%) | 2 (2.7%) | 72 (97.3%) |
| UC whole group | 275 | n.o. | 9 (3.3%) | 265 (96.7%) | 9 (1.6%) | 539 (98.4%) |
| CD adults | 217 | n.o. | 30 (13.9%) | 186 (86.1%) | 30 (6.9%) | 402 (93.1%) |
| CD adult women | 117 | n.o. | 16 (13.7%) | 101 (86.3%) | 16 (6.8%) | 218 (93.2%) |
| CD adult men | 100 | n.o. | 14 (14.1%) | 85 (85.9%) | 14 (7.1%) | 184 (92.9%) |
| CD children | 85 | n.o. | 11 (12.9%) | 74 (87.1%) | 11 (6.5%) | 159 (93.5%) |
| CD girls | 41 | n.o. | 3 (7.3%) | 38 (92.7%) | 3 (3.7%) | 79 (96.3%) |
| CD boys | 44 | n.o. | 8 (18.2%) | 36 (81.8%) | 8 (9.1%) | 80 (90.9%) |
| CD whole group | 302 | n.o. | 41 (13.6%) | 260 (86.4%) | 41 (6.8%) | 561 (93.2%) |
| Controls | 539 | n.o. | 11 (4.0%) | 266 (96.0%). | 11 (2.0%) | 543 (98.0%) |
| (TT) vs. (CC) OR 95% CI p-value |
(TC) vs. (CC) OR 95% CI p-value |
(TT) + (TC) vs. (CC) OR 95% CI p-value |
(T) vs. (C) OR 95% CI p-value |
|||
| IBD whole group vs. controls | n.a. |
OR = 2.30
CI = (1.18–4.50) p = 0.012 |
n.a. |
OR = 2.24
CI = (1.16–4.35) p = 0.014 |
||
| UC adults vs. controls | n.a. | OR = 0.59 CI = (0.20–1.73) p = 0.334 |
n.a. | OR = 0.60 CI = (0.21–1.73) p = 0.338 |
||
| UC children vs. controls | n.a. | OR = 1.59 CI = (0.49–5.15) p = 0.439 |
n.a. | OR = 1.57 CI = (0.49–5.00) p = 0.502 |
||
| UC adults vs. UC children | n.a. | OR = 0.37 CI = (0.10–1.44) p = 0.137 |
n.a. | OR = 0.38 CI = (0.10–1.44) p = 0.263 |
||
| UC women vs. UC men | n.a. | OR = 0.28 CI = (0.03–2.56) p = 0.231 |
n.a. | OR = 0.29 CI = (0.03–2.57) p = 0.382 |
||
| UC girls vs. UC boys | n.a. | OR = 1.35 CI = (0.18–10.19) p = 0.773 |
n.a. | OR = 1.33 CI = (0.18–9.77) p = 1.005 |
||
| UC whole group vs. controls | n.a. | OR = 0.82 CI = (0.34–2.01) p = 0.667 |
n.a. | OR = 0.82 CI = (0.34–2.01) p = 0.670 |
||
| CD adults vs. controls | n.a. |
OR = 3.90
CI = (1.91–7.98) p < 0.001 |
n.a. |
OR = 3.68
CI = (1.82–7.44) p < 0.001 |
||
| CD children vs. controls | n.a. |
OR = 3.60
CI = (1.50–8.62) p = 0.002 |
n.a. |
OR = 3.42
CI = (1.45–8.02) p = 0.003 |
||
| CD adults vs. CD children | n.a. | OR = 1.09 CI = (0.52–2.28) p = 0.829 |
n.a. | OR = 1.08 CI = (0.53–2.21) p = 0.835 |
||
| CD women vs. CD men | n.a. | OR = 0.96 CI = (0.44–2.08) p = 0.921 |
n.a. | OR = 0.97 CI = (0.46–2.03) p = 0.924 |
||
| CD girls vs. CD boys | n.a. | OR = 0.36 CI = (0.09–1.45) p = 0.136 |
n.a. | OR = 0.38 CI = (0.10–1.48) p = 0.150 |
||
| CD whole group vs. controls | n.a. |
OR = 3.81
CI = (1.92–7.58) p < 0.001 |
n.a. |
OR = 3.61
CI = (1.84–7.09) p < 0.001 |
||
| CD whole group vs. UC whole group | n.a. |
OR = 4.64
CI = (2.21–9.75) p < 0.001 |
n.a. |
OR = 4.38
CI = (2.11–9.09) p < 0.001 |
||
Statistically significant results are marked in bold; n.o.: not observed; n.a.: not analyzed (TT genotype was not detected).