Table 3.
Allele and genotype distribution for the NOD2 c.2722G>C (p.G908R, rs2066845) variant.
| c.2722G>C (p.G908R) rs2066845 |
Genotypes n (%) |
Alleles n (%) |
||||
|---|---|---|---|---|---|---|
| Group | n | CC | GC | GG | C | G |
| IBD whole group | 578 | 1 (0.2%) | 41 (7.1%) | 536 (92.7%) | 43 (3.7%) | 1113 (96.3%) |
| UC adults | 211 | n.o. | 16 (7.6%) | 195 (92.4%) | 16 (3.8%) | 406 (96.2%) |
| UC adult women | 99 | n.o. | 7 (7.1%) | 92 (92.9%) | 7 (3.5%) | 191 (96.5%) |
| UC adult man | 112 | n.o. | 9 (8.1%) | 103 (91.9%) | 9 (4%) | 215 (96%) |
| UC children | 65 | n.o. | 1 (1.5%) | 64 (98.5%) | 1 (0.8%) | 129 (99.2%) |
| UC girls * | 28 | n.o. | n.o. | 28 (100%) | 0 (0%) | 56 (100%) |
| UC boys | 37 | n.o. | 1 (2.7%) | 36 (97.3%) | 1 (1.3%) | 73 (98.7%) |
| UC whole group | 276 | n.o. | 17 (6.2%) | 259 (93.8%) | 17 (3.1%) | 535 (96.9%) |
| CD adults | 217 | 1 (0.5%) | 14 (6.5%) | 202 (93%) | 16 (3.7%) | 418 (96.3%) |
| CD adult women | 117 | 1 (0.9%) | 10 (8.5%) | 106 (90.6%) | 12 (5.1%) | 222 (94.9%) |
| CD adult men | 100 | n.o. | 4 (4%) | 96 (%) | 4(2%) | 196 (98%) |
| CD children | 85 | n.o. | 10 (11.8%) | 75 (88.2%) | 10 (5.9%) | 160 (94.1%) |
| CD girls | 41 | n.o. | 3 (7.3%) | 38 (92.7%) | 3 (3.7%) | 79 (96.3%) |
| CD boys | 44 | n.o. | 7 (15.9%) | 37 (84.1%) | 7 (7.9%) | 81 (92.1%) |
| CD whole group | 302 | 1 (0.4%) | 24 (7.9%) | 277 (91.7%) | 26 (4.3%) | 578 (95.7%) |
| Controls | 715 | n.o. | 15 (2.1%) | 700 (97.9%). | 15 (1.1%) | 1415 (98.9%) |
| (CC) vs. (GG) OR 95% CI p-value |
(GC) vs. (GG) OR 95% CI p-value |
(CC) + (GC) vs. (GG) OR 95% CI p-value |
(C) vs. (G) OR 95% CI p-value |
|||
| IBD vs. controls | OR = 3.49 CI = (0.14–85.92) p = 0.280 |
OR = 1.09 CI = (0.04–28.30) p = 0.551 |
OR = 3.34 CI = (0.13–82.02) p = 0.291 |
OR = 3.34
CI = (1.85–6.02) p < 0.001 |
||
| UC adults vs. controls | n.a. | OR = 0.89 CI = (0.02–47.36) p = 1.000 |
OR = 3.37 CI = (0.07–170.19) p = 1.000 |
OR = 3.94
CI = (1.95–7.96) p < 0.001 |
||
| UC children vs. controls | n.a. | OR = 10.33 CI = (0.14–734.03) p = 1.000 |
OR = 10.92 CI = (0.21–555.02) p = 1.000 |
OR = 0.73 CI = (0.09–5.58) p = 1.000 |
||
| UC adults vs. UC children | n.a. | OR = 0.08 CI = (0.00–6.06) p = 1.000 |
OR = 0.31 CI = (0.00–15.69) p = 1.000 |
OR = 5.38 CI = (0.71–40.88) p = 0.089 |
||
| UC women vs. UC men | n.a. | OR = 1.27 CI = (0.02–71.63) p = 1.000 |
OR = 1.13 CI = (0.02–57.51) p = 1.000 |
OR = 0.87 CI = (0.32–2.39) p = 0.795 |
||
| UC girls vs. UC boys | n.a. | OR = 3.00 CI = (0.02–473.06) p = 1.000 |
OR = 1.32 CI = (0.02–68.34) p = 1.000 |
OR = 0.43 CI = (0.01–10.85) p = 1.203 |
||
| UC whole group vs. controls | OR = 2.16 CI = (0.04–109.03) p = 1.000 |
OR = 0.83 CI = (0.02–44.73) p = 1.000 |
OR = 2.09 CI = (0.04–105.50) p = 1.000 |
OR = 2.55
CI = (1.27–5.09) p = 0.006 |
||
| CD adults vs. controls | OR = 10.38 CI = (0.42–255.72) p = 0.063 |
OR = 3.21 CI = (0.12–85.20) p = 0.309 |
OR = 9.91 CI = (0.40–244.26) p = 0.069 |
OR = 3.61
CI = (1.77–7.36) p < 0.001 |
||
| CD children vs. controls | n.a. | OR = 1.47 CI = (0.02–80.39) p = 1.000 |
OR = 8.37 CI = (0.16–424.45) p = 1.000 |
OR = 5.89
CI = (2.60–13.34) p < 0.001 |
||
| CD adults vs. CD children | OR = 1.12 CI = (0.04–27.76) p = 0.542 |
OR = 2.17 CI = (0.08–58.76) p = 0.405 |
OR = 1.18 CI = (0.05–29.37) p = 0.530 |
OR = 0.61 CI = (0.27–1.38) p = 0.232 |
||
| CD women vs. CD men | OR = 2.71 CI = (0.11–67.52) p = 0.342 |
OR = 1.28 CI = (0.04–37.98) p = 0.532 |
OR = 2.58 CI = (0.10–64.24) p = 0.354 |
OR = 2.65 CI = (0.85–8.35) p = 0.085 |
||
| CD girls vs. CD boys | n.a. | OR = 2.14 CI = (0.03–131.93) p = 1.000 |
OR = 1.07 CI = (0.02–55.28) p = 1.000 |
OR = 0.44 CI = (0.11–1.76) p = 0.332 |
||
| CD whole group vs. controls | OR = 7.57 CI = (0.31–186.46) p = 0.112 |
OR = 1.89 CI = (0.07–49.60) p = 0.433 |
OR = 7.11 CI = (0.29–175.26) p = 0.124 |
OR = 4.24
CI = (2.23–8.07) p < 0.001 |
||
| CD whole group vs. UC whole group | OR = 3.50 CI = (0.14–86.46) p = 0.279 |
OR = 2.26 CI = (0.08–58.83) p = 0.390 |
OR = 3.40 CI = (0.14–83.97) p = 0.287 |
OR = 1.66 CI = (0.90–3.06) p = 0.099 |
||
Statistically significant results are marked in bold; n.o.: not observed; n.a.: not analyzed (CC genotype was not detected in both juxtaposed groups); *: deviation from HWE.