Table 4.
Allele and genotype distribution for NOD2 c.2798+158C>T (rs5743289) polymorphism.
| c.2798 + 158C>T rs5743289 |
Genotypes n (%) |
Alleles n (%) |
||||
|---|---|---|---|---|---|---|
| Group | n | TT | TC | CC | T | C |
| IBD whole group | 348 | 26 (7.5%) | 108 (31.0%) | 214 (61.5%) | 160 (23.0%) | 536 (77.0%) |
| UC adults | 111 | 4 (3.6%) | 24 (21.6%) | 83 (74.8%) | 32 (14.4%) | 190 (85.6%) |
| UC adult women | 57 | 2 (3.5%) | 12 (21.1%) | 43 (75.4%) | 16 (14.0%) | 98 (86.0%) |
| UC adult men | 54 | 2 (3.7%) | 12 (22.2%) | 40 (74.1%) | 16 (14.8%) | 92 (85.2%) |
| UC children | 62 | n.o. | 21 (33.9%) | 41 (66.1%) | 21 (16.9%) | 103 (83.1%) |
| UC girls | 25 | n.o. | 10 (40.0%) | 15 (60.0%) | 10 (20%) | 40 (80%) |
| UC boys | 37 | n.o. | 11 (29.7%) | 26 (70.3%) | 11 (14.9%) | 63 (85.1%) |
| UC whole group | 173 | 4 (2.3%) | 45 (26.0%) | 124 (71.7%) | 53 (15.3%) | 293 (84.7%) |
| CD adults | 97 | 6 (6.2%) | 38 (39.2%) | 53 (54.6%) | 50 (25.8%) | 144 (74.2%) |
| CD adult women | 49 | 4 (8.2%) | 23 (46.9%) | 22 (44.9%) | 31 (31.6%) | 67 (68.4%) |
| CD adult men | 48 | 2 (4.2%) | 15 (31.2%) | 31 (64.6%) | 19 (19.8%) | 77 (80.2%) |
| CD children | 78 | 16 (20.5%) | 25 (32.1%) | 37 (47.4%) | 57 (36.5%) | 99 (63.5%) |
| CD girls | 39 | 7 (18.0%) | 13 (33.3%) | 19 (48.7%) | 27 (34.6%) | 51 (65.4%) |
| CD boys | 39 | 9 (23.1%) | 12 (30.8%) | 18 (46.1%) | 30 (38.5%) | 48 (61.5%) |
| CD whole group | 175 | 22 (12.6%) | 63 (36.0%) | 90 (51.4%) | 107 (30.6%) | 243 (69.4%) |
| Controls | 231 | 10 (4.3%) | 59 (25.5%) | 162 (70.1%) | 79 (17.1%) | 383 (82.9%) |
| (TT) vs. (CC) OR 95% CI p-value |
(TC) vs. (CC) OR 95% CI p-value |
(TT) + (TC) vs. (CC) OR 95% CI p-value |
(T) vs. (C) OR 95% CI p-value |
|||
| IBD whole group vs. controls | OR = 1.97 CI = (0.92–4.20) p = 0.075 |
OR = 1.42 CI = (0.64–3.15) p = 0.386 |
OR = 1.47 CI = (1.03–2.10) p = 0.033 |
OR = 1.45
CI = (1.07–1.95) p = 0.015 |
||
| UC adults vs. controls | OR = 0.78 CI = (0.24–2.58) p = 0.683 |
OR = 0.98 CI = (0.28–3.44) p = 0.979 |
OR = 0.79 CI = (0.47–1.32) p = 0.372 |
OR = 0.82 CI = (0.52–1.28) p = 0.373 |
||
| UC children vs. controls | OR = 0.19 CI = (0.01–3.25) p = 0.114 |
OR = 0.13 CI = (0.01–2.35) p = 0.064 |
OR = 1.20 CI = (0.66–2.18) p = 0.544 |
OR = 0.99 CI = (0.58–1.68) p = 0.966 |
||
| UC adults vs. UC children | OR = 4.47 CI = (0.24–85.07) p = 0.163 |
OR = 7.90 CI = (0.40–155.28) p = 0.071 |
OR = 0.66 CI = (0.33–1.30) P = 0.226 |
OR = 0.83 CI = (0.45–1.51) p = 0.532 |
||
| UC women vs. UC men | OR = 0.93 CI = (0.13-6.92) p = 0.944 |
OR = 1.00 CI = (0.12–8.31) p = 1.00 |
OR = 0.93 CI = (0.40–2.19) p = 0.869 |
OR = 0.94 CI = (0.44-1.99) p = 0.869 |
||
| UC girls vs. UC boys | OR = 1.71 CI = (0.03–90.56) p = 1.00 |
OR = 1.10 CI = (0.02–60.29) p = 1.00 |
OR = 1.58 CI = (0.54–4.58) p = 0.402 |
OR = 1.43 CI = (0.56–3.68) p = 0.455 |
||
| UC whole group vs. controls | OR = 0.52 CI = (0.16–1.71) p = 0.275 |
OR = 0.52 CI = (0.15–1.78) p = 0.295 |
OR = 0.93 CI = (0.66–1.43) p = 0.735 |
OR = 0.88 CI = (0.60–1.28) p = 0.498 |
||
| CD adults vs. controls | OR = 1.83 CI = (0.64–5.29) p = 0.256 |
OR = 0.93 CI = (0.31–2.77) p = 0.899 |
OR = 1.95 CI = (1.20–3.18) p = 0.007 |
OR = 1.68
CI = (1.13–2.52) p = 0.011 |
||
| CD children vs. controls |
OR = 7.01
CI = (2.94–16.67) p < 0.001 |
OR = 3.78
CI = (1.51–9.46) p = 0.003 |
OR = 2.60
CI = (1.54–4.40) p < 0.001 |
OR = 2.79
CI = (1.86–4.19) p < 0.001 |
||
| CD adults vs. CD children |
OR = 0.26
CI = (0.09–0.73) p = 0.008 |
OR = 0.25
CI = (0.09–0.72) p = 0.008 |
OR = 0.75 CI = (0.41–1.36) p = 0.343 |
OR = 0.60
CI = (0.38–0.95) p = 0.030 |
||
| CD women vs. CD men | OR = 2.82 CI = (0.47–16.76) p = 0.239 |
OR = 1.30 CI = (0.21–8.03) p = 0.774 |
OR = 2.24 CI = (0.99–5.06) p = 0.052 |
OR = 1.88 CI = (0.97–3.62) p = 0.059 |
||
| CD girls vs. CD boys | OR = 0.74 CI = (0.23–2.40) p = 0.611 |
OR = 0.72 CI = (0.20–2.54) p = 0.606 |
OR = 0.90 CI = (0.37–2.20) p = 0.821 |
OR = 0.85 CI = (0.44–1.63) p = 0.618 |
||
| CD whole group vs. controls |
OR = 3.96
CI = (1.80–8.73) p < 0.001 |
OR = 2.06 CI = (0.90–4.71) p = 0.083 |
OR = 2.22
CI = (1.47–3.34) p < 0.001 |
OR = 2.14
CI = (1.53–2.98) p < 0.001 |
||
| CD whole group vs. UC whole group |
OR = 7.58
CI = (2.52–22.75) p < 0.001 |
OR = 3.93
CI = (1.27–12.19) p = 0.013 |
OR = 2.39
CI = (1.53–3.73) p < 0.001 |
OR = 2.43
CI = (1.68–3.53) p < 0.001 |
||
Statistically significant values are marked in bold; n.o.: not observed.