Table 6.
NOD2 gene haplotypes and association analysis.
| Name * | Alleles/Haplotypes | Frequency ** | Disease Entity CD vs. UC |
Crohn’s Disease | Ulcerative Colitis | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Predisposition to Late-Onset Form | Predisposition to Early-Onset Form | Sex (Women vs. Men) |
Predisposition to Late-Onset Form | Predisposition to Early-Onset Form | Sex (Women vs. Men) |
|||||||||||||||||
| p.P268S | p.R702W | p.G908R | c.2798 +158C>T |
1007fs | Controls | CD | UC | OR (95% CI) |
p-Value | OR (95% CI) |
p-Value | OR (95% CI) |
p-Value | OR (95% CI) |
p-Value | OR (95% CI) |
p-Value | OR (95% CI) |
p-Value | OR (95% CI) |
p-Value | |
| A | C | C | G | C | wt. | 39.5% | 50.3% | 72.0% |
0.40
(0.32–0.51) |
< 0.001 |
1.77
(1.27–2.48) |
< 0.001 | 1.26 (0.87–1.82) |
0.241 | 0.61 (0.35–1.08) |
0.091 |
3.40
(2.43–4.78) |
< 0.001 |
2.67
(1.77–4.01) |
< 0.001 | 1.17 (0.66–2.07) |
0.598 |
| - | C | C | C | C | wt. | 25.4% | n.o. | n.o. | n.a. | - |
0.01
(0.00–0.12) |
< 0.001 |
0.03
(0.01–0.16) |
< 0.001 | n.a. | - |
0.03
(0.01–0.11) |
< 0.001 |
0.02
(0.01–0.17) |
< 0.001 | n.a. | - |
| H | T | C | G | C | wt. | 8.2% | 9.7% | 7.2% | 1.24 (0.81–1.88 |
0.323 | 1.35 (0.77–2.35) |
0.297 | 1.44 (0.80–2.59) |
0.195 | 0.75 (0.29–1.96) |
0.561 | 1.04 (0.59–1.85) |
0.883 | 1.74 (0.95–3.19) |
0.074 | 0.67 (0.25–1.84) |
0.440 |
| D | T | C | C | C | wt. | 5.2% | 3.1% | 1.7% | 1.88 (0.90–3.93) |
0.095 |
0.10
(0.01–0.72) |
0.023 | 0.50 (0.17–1.46) |
0.206 | 7.69 (0.39–150.88) |
0.179 |
0.34
(0.12–1.00) |
0.051 | 0.15 (0.02–1.11) |
0.063 | 1.49 (0.24–9.07) |
0.668 |
| – | T | C | C | T | wt. | 4.3% | n.o. | n.o. | n.a. | - |
0.12
(0.02–0.88) |
0.037 | 0.07 (0.01–1.19) |
0.066 | n.a. | – |
0.10
(0.01–0.77) |
0.027 | 0.09 (0.01–1.46) |
0.090 | n.a. | - |
| G | T | C | G | T | wt. | 4.2% | 9.0% | 6.8% | 1.28 (0.82–1.99) |
0.283 | 1.89 (0.95–3.78) |
0.071 |
2.97
(1.50–5.88) |
0.002 | 3.18 (0.98–10.37) |
0.055 |
2.00
(1.04–3.87) |
0.039 |
2.61
(1.26–5.41) |
0.010 | 1.51 (0.56–4.05) |
0.412 |
| E | T | C | G | T | insC | 3.5% | 13.3% | 3.3% |
4.13
(2.55–6.71) |
< 0.001 |
5.09
(2.59–9.97) |
< 0.001 |
4.62
(2.26–9.47) |
< 0.001 | 1.28 (0.56–2.94) |
0.555 | 0.76 (0.27–2.13) |
0.598 | 1.92 (0.76–4.85) |
0.170 | 0.65 (0.11–3.96) |
0.639 |
| - | T | C | C | T | insC | 2.1% | n.o. | n.o. | n.a. | - | 0.11 (0.01–1.95) |
0.134 | 0.61 (0.13–2.82) |
0.527 | n.a. | - | 0.10 (0.01–1.70) |
0.111 | 0.10 (0.01–3.00) |
0.229 | n.a. | - |
| - | C | C | G | C | insC | 1.9% | 1.6% | 2.0% | 0.70 (0.28–1.75) |
0.447 | 1.08 (0.33–3.56) |
0.897 | 1.02 (0.27–3.82) |
0.977 | 0.53 (0.05–5.91) |
0.603 | 2.17 (0.85–5.55) |
0.105 | 0.41 (0.05–3.29) |
0.404 | 1.24 (0.32–4.74) |
0.755 |
| - | C | C | C | C | insC | 1.7% | n.o. | n.o. | n.a. | - | 0.14 (0.01–2.46) |
0.179 | 0.18 (0.01–3.10) |
0.274 | n.a. | - | 0.12 (0.01–2.15) |
0.151 | 0.22 (0.01–3.78) |
0.295 | n.a. | - |
| - | C | C | C | T | wt. | 1.4% | n.o. | n.o. | n.a. | - | 0.16 (0.01–2.82) |
0.211 | 0.20 (0.01–3.55) |
0.274 | n.a. | - | 0.14 (0.01-2.46) |
0.179 | 0.25 (0.01–4.34) |
0.339 | n.a. | - |
| - | T | C | G | C | insC | n.o. | 2.8% | 1.9% |
2.47
(1.08–5.64) |
0.033 |
23.01
(2.90–182.91) |
0.003 | n.a. | - | 1.08 (0.30–3.85) |
0.907 | n.a. | - |
3.73
(1.06–13.08) |
0.040 | n.a. | - |
| B | T | T | G | T | wt. | n.o. | 5.1% | 1.6% |
2.90
(1.40–6.00) |
0.004 |
17.71
(2.16–144.90) |
0.007 |
29.36
(3.69–233.68) |
0.001 | 3.34 (0.66–16.98) |
0.146 | n.a. | - | 1.81 (045–7.35) |
0.405 | n.a. | - |
| - | C | C | G | T | wt. | n.o. | 2.4% | n.o. | 1.33 (0.53–3.34 |
0.537 | n.a. | - |
12.93
(2.72–61.58) |
0.001 | n.a. | - | n.a. | - | n.a. | - | n.a. | - |
Statistically significant results and minor alleles are marked in bold; wt.: wild type allele (in this case: allele without insertion); *: according to Tukel et al.; **: haplotype frequencies evaluated and rounded using Haploview; n.a.: not analyzed; n.o.: not observed.